Compare GLP-1 Provider
Prices for 2026

For compounded semaglutide, Yucca Health currently offers the lowest sustained pricing — from $146/month on a 6-month plan for new patients, or $175/month for the first month on a monthly plan. Ro offers an FDA-approved oral semaglutide pill from $149/month for the first month (membership fee separate). Strut Health and Gala start at $199/month. These prices are all dramatically lower than branded Wegovy at $1,349/month without insurance.

Compounded semaglutide contains the same active ingredient — semaglutide — as Wegovy and Ozempic. The difference is in the manufacturing process. Branded medications are FDA-approved finished products manufactured by Novo Nordisk. Compounded versions are prepared by licensed US compounding pharmacies under strict standards, but are not FDA-approved as finished drug products. The clinical evidence base (STEP 1 and SURMOUNT-1 trials) applies to the branded versions. Many patients use compounded versions successfully, but the regulatory status differs. Always choose a provider working with a licensed US 503A or 503B compounding pharmacy.

Clinical trials show tirzepatide produces greater average weight loss — approximately 20–22% of body weight at maximum dose compared to semaglutide's 15%. However, tirzepatide costs $100–150/month more through most providers. Semaglutide is a proven, well-tolerated medication with a longer track record. For most first-time GLP-1 patients, semaglutide is the right starting point. Tirzepatide may be worth the premium if you need maximum weight loss results, have type 2 diabetes, or have previously tried semaglutide without adequate response. Use our weight loss timeline calculator to compare projected results for both medications.

Most telehealth providers offering compounded GLP-1 medications do not accept insurance, since compounded medications are not FDA-approved and are typically excluded from formularies. Ro is the exception — they offer FDA-approved branded GLP-1s (Wegovy, Zepbound) at the lowest available cash prices, and include an insurance concierge service that helps you get coverage. If you have commercial insurance, it's worth checking coverage before paying cash prices. Use our insurance coverage estimator to assess your likelihood of coverage. HSA and FSA cards are accepted by most providers on this list.

Clinical trials show that most of the weight lost on GLP-1 medications returns within 12–18 months of stopping treatment. GLP-1 medications are increasingly being considered long-term treatments rather than short courses. When comparing providers, consider the ongoing monthly cost rather than just the introductory price — this is what you will actually pay. Use our monthly cost calculator to estimate your 12 and 24-month total investment.