Question 1

What is the Wegovy dosing schedule week by week?

Accepted Answer

The Wegovy (semaglutide 2.4mg) titration schedule follows a 16-week ramp-up. Weeks 1 to 4: 0.25mg weekly. Weeks 5 to 8: 0.5mg weekly. Weeks 9 to 12: 1.0mg weekly. Weeks 13 to 16: 1.7mg weekly. Week 17 onward: 2.4mg weekly maintenance dose. Each increase allows your body to adjust and minimise gastrointestinal side effects. Nausea and constipation are most common at the start and typically improve after 2 to 4 weeks at each dose level. If side effects are significant, your physician can slow the titration schedule by spending additional weeks at any dose level — this is clinically appropriate and does not reduce long-term effectiveness.

Question 2

What is the Zepbound and Mounjaro dosing schedule?

Accepted Answer

The Zepbound and Mounjaro (tirzepatide) titration schedule starts at 2.5mg per week for weeks 1 to 4, then 5.0mg per week for weeks 5 to 8. Optional further titration: 7.5mg at weeks 9 to 12, 10mg at weeks 13 to 16, 12.5mg at weeks 17 to 20, and 15mg maximum dose from week 21 onward. Not all patients need to reach 15mg — many achieve their weight loss goals at 5 to 10mg. Your physician will guide dose escalation based on your response and tolerability. The SURMOUNT-1 trial showed that higher doses of 10 to 15mg produced meaningfully greater weight loss than lower doses, so dose optimisation matters for maximum results.

Question 3

What day of the week should I take my GLP-1 injection?

Accepted Answer

Any day of the week works for your GLP-1 injection — the most important factor is consistency, not which day you choose. Pick a day you can reliably remember: many patients choose Monday, Friday, or a day with a built-in calendar reminder. If you want to shift your injection day, you can do so as long as at least 4 days have passed since the previous injection, then resume the new weekly schedule from that point. Use this dose schedule calculator to automatically calculate all your future injection dates once you enter your start date and medication type.

Question 4

What happens if I miss a GLP-1 dose?

Accepted Answer

If you miss a dose of Wegovy, Ozempic, Zepbound, or Mounjaro, inject it as soon as you remember, provided no more than 5 days have passed since your scheduled injection date. If more than 5 days have passed, skip the missed dose entirely and resume your regular weekly schedule on the next scheduled day — do not double up. Missing one or two doses is unlikely to significantly impact your progress, as the medication has a half-life of approximately 7 days. Consistent weekly dosing is important for maintaining steady blood levels and sustained appetite suppression. If you frequently miss doses, switching your injection day to a more convenient day may improve adherence.

Question 5

How long until GLP-1 medication starts working?

Accepted Answer

Most people notice reduced appetite and early weight loss within 2 to 4 weeks of starting GLP-1 medication. Appetite suppression begins at the lowest titration dose, though the effect is more pronounced at higher doses. Clinically meaningful weight loss — 5% of body weight — is usually achieved between weeks 8 and 16 on standard titration. Blood sugar improvements for diabetic patients often occur within the first 1 to 2 weeks. If you have been on the starting dose for 4 to 6 weeks without any appetite suppression or weight change, discuss with your provider whether to accelerate titration — some patients respond slowly at lower doses.

Question 6

Can I slow down my GLP-1 titration schedule?

Accepted Answer

Yes, and this is commonly recommended. Staying at any dose level for an additional 4 to 8 weeks is clinically appropriate and does not reduce long-term effectiveness. If you experience significant nausea, vomiting, fatigue, or other side effects when increasing your dose, holding at the current level allows your body to adjust before moving up. Studies show that patients who titrate more slowly have comparable total weight loss to those on standard schedules, with better tolerability and lower dropout rates. Some providers offer extended titration protocols of 20 to 24 weeks to reach maintenance dose. Always make dose schedule changes with your prescribing physician.

GLP-1 Dose ScheduleCalculator

Wegovy dosing schedule week by week

Zepbound and Mounjaro dosing schedule

GLP-1 Dose Schedule
Calculator